10 Reviews: Best Flea Control for Big Dogs (Apr 2024)

Frontline Plus is a flea and tick treatment for puppies and kittens aged 8 weeks and above that need the most comprehensive flea and tick protection available. Frontline Plus not only kills up to 100% of adult fleas on your pet in 24 hours, but it also includes a specific chemical that destroys flea eggs and larvae, preventing all stages of fleas from maturing and causing irritation to your pet and family. Frontline Plus efficiently stops the flea life cycle by preventing the creation of new fleas. Frontline Plus also kills all stages of four ticks, including the Lyme disease-causing insect.

This easy-to-use spray provides immediate relief from biting fleas for your dog. Adult fleas, flea eggs, flea larvae, and ticks are all killed, and the flea life cycle is disrupted for up to two months. It also works as a mosquito repellent. For up to two months, this spray keeps flea eggs from hatching. Adams Plus Flea and Tick Spray combine etofenprox’s adult flea killing strength with S-methoprene Insect Growth Regulator’s long-lasting flea egg-killing ability. This potent combination of chemicals gives immediate relief from biting fleas as well as the ongoing destruction of flea eggs deposited on the animal, thereby interrupting the flea life cycle.

I have used this for years when I have taken my dog to the country to protect her from fleas and ticks. It has worked every time.She is comfortable and we are not bringing unwanted insects home with us. Nothing worse than having flea and tick infestations in your home. Prevention does work!!

by Patricia Steger

Another monthly topical flea medication, Advantage II, destroys adult fleas and larvae before they develop (but not ticks). It’s non-toxic and keeps fleas away from your dog. Advantage II is a topical flea treatment for dogs that is applied to the skin and hair. Fleas don’t have to bite your dog to perish since Advantage II kills them via touch. Fleas must bite your dog and consume the medicine before being destroyed by oral flea treatments.

I use this each month, (along with heartworm meds), and I spray the yard periodically with Pet Safe flea spray. We don't have a flea problem doing this. It's easy to use, once a month, and doesn't bother their skin. Must follow directions.

by Elizabeth Billeaudeaux

You can remove fleas and ticks while keeping your dog clean with this Adams dog shampoo. With aloe, lanolin, coconut extract, and oatmeal in the composition, it’s gentle on both your and your dog’s skin—and it smells fantastic, too. The bottle should last a long time since a little one goes a long way. According to the manufacturers, the shampoo contains an insect growth regulator (IGR) that may kill fleas and prevent them from growing for up to 28 days.

Worked great. My poor dog must have been super infested or the other stuf we used previous just wasnt good enough. I would definitely buy this again.

by Gabe

This is an all-natural flea and tick repellant for dogs that can be sprayed. Wondercide is a home flea and tick prevention spray developed by a pet owner whose dog became ill after using standard flea and tick control methods. It’s made up of natural oils and compounds derived from plants. It’s safe for cats and dogs, and it may also be sprayed on bedding, which is where fleas hide once they’ve found their way inside. The Wondercide comes in a spray bottle, so you may spray it on your pet’s hair and massage it in. It has a lemongrass scent and no chemical odor.

Smells great. Could visibly see it working on our cats and could see dead bugs coming off them the next day. For the price, this is the best flea/tick solution i have came across. Definitely recommend!

by Spencer W.

K9 Advantix II Flea and tick prevention for extra-large dogs is a broad-spectrum, veterinarian-recommended flea and tick preventative that also kills and repels mosquitos. Some flea and tick prevention treatments need a flea or tick to bite your dog to work, but K9 Advantix II Flea and tick prevention for dogs is a topical composition that works via touch, so the flea, tick, or mosquito does not have to bite your dog to die. One application of Bayer K9 Advantix II Flea and tick prevention for extra-large dogs kills fleas in as little as 12 hours, is waterproof after 24 hours, and kills fleas, ticks, and mosquitoes for up to 30 days, even after a wash or swimming.

We have been using this on our dogs for a little over a year and have had no problems with ticks or fleas. We live in the country and we have noticed our dogs are no where near effected by fleas and ticks like our neighbors dogs. The price on Amazon has stayed within the dollar compared to chewy.

by Jessica M.

Fleas, flea eggs, flea larvae, ticks, and chewing lice are all killed by SENTRY Fiproguard Plus. SENTRY Fiproguard Plus is a squeeze-on intended to protect your dog against hazardous bugs. It is fast-acting and long-lasting. It eliminates ticks that may transmit Lyme disease and disrupts the flea life cycle by destroying flea eggs and larvae. For up to 12 weeks, this treatment may disrupt the flea life cycle and destroy flea eggs and larvae.

Great value for your money and works fantastically! I’ve tried other products that didn’t work nowhere near as well. Will continue to stick with this product moving forward!

by Stacy Lewis

Capstar for Dogs is the only non-prescription flea control product suitable for puppies as young as four weeks old and weighing at least two pounds. The key ingredient in Capstar, nitenpyram, begins functioning in 30 minutes and kills over 90% of adult fleas on dogs in only four hours. Although Capstar’s flea protection is only effective for 24 hours, it is okay to apply it every day if necessary. This is especially useful for puppies who aren’t yet old enough to take a long-term protective oral or topical therapy.

I live in florida where bugs of all kinds flourish. Until I started using this product, i would flea comb 50 fleas off my dog at a time several times a week. now i give her this product once a week and never see a flea on her. it really works.

by anna rice

Seresto Flea and Tick Collar for Dogs uses sustained-release technology to protect dogs for up to eight months against adult fleas, flea larvae, four different kinds of ticks, chewing lice, and mange mites. The collar is odorless, non-greasy, lightweight, and fits dogs of all sizes. It has a two-step safety system that prevents your dog from being wounded if the collar catches on anything. Imidacloprid and flumethrin are applied to your dog’s skin and hair in little amounts to killing fleas and ticks that come into contact with the Seresto Flea and Tick Collar for Dogs.

I have been using these for years and they work amazing!! I have bought off brands trying to save money and it wasn't worth it they were a waste these don't irritate any of my dogs and they work!!! I have never found a flea or tick on them with this on or a bite of any kind to be honest. I love how they're water proof and don't smell. I will never go with a different one ever again

by Hannah

Using veterinarian-recommended chemicals, PetArmor Plus Flea & Tick Spot Treatment for Dogs eliminates fleas, larvae, eggs, and ticks. Fipronil and (s)-methoprene, which is both contained in this product, kill bugs on contact and stop the flea reproductive cycle, preventing further infestations and providing protection for up to 12 weeks. PetArmor Plus is available in four different dosages for different sized puppies: the 5-22 pound dose is for puppies aged 8 weeks and above who weigh between 5 and 22 pounds.

Put this on my dog and 3 weeks later we went out in the country to play. I stayed in the short grass while she ran all over the place. When we got home I had 5+ ticks on me and she had 0.

by user